systems medicine


The EU H2020 project REPO-TRIAL aims at developing an _in silico_ approach to optimise the efficacy and precision of drug repurposing trials. To this end we integrate heterogeneous data into a comprehensive interactome of disease-drug-gene interactions (a new diseasome) and develop graph-based machine learning approaches to investigate this highly complex data.

Network-Based Epistasis Detection

We tackle the challenge of higher-order epistasis detection using biological networks to narrow the search space and GPU computing to improve the efficiency. Phenotype-specific epistasis-modules extracted from larger networks will help to better understand the underlying biological mechanisms of different phenotypes.