Publications

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Changes in intestinal microbiome composition are associated with inflammatory, metabolic, and malignant disorders. We studied how …

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. …

OMICs subsume different physiological layers including the genome, transcriptome, proteome and metabolome. Recent advances in …

The incidence of neuroendocrine neoplasias (NEN) continues to increase. Since the primary tumor cannot be diagnosed in some cases of …

In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human …

The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that …

Systems biology models are rapidly increasing in complexity, size and numbers. When building large models, researchers rely on software …

Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely …

Using oral contraceptives has been implicated in the aetiology of stress-related disorders like depression. Here, we followed the …

MicroRNAs (miRNA) are important non-coding modulators controlling patterns of gene expression. However, profiling and validation of …

Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen …

Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution …

Caffeine is the most widely consumed psychoactive substance in the world and presents with wide interindividual variation in …

Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have …

Ionizing radiation is known to induce genomic lesions, such as DNA double strand breaks, whose repair can lead to mutations that can …

Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets’ important roles in …

White blood cells play diverse roles in innate and adaptive immunity. Genetic association analyses of phenotypic variation in …

Red blood cell (RBC) traits are important heritable clinical biomarkers and modifiers of disease severity. To identify coding genetic …

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and …

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by early intraneuronal amyloid-β (Aβ) …

Non-cellular blood circulating microRNAs (plasma miRNAs) represent a promising source for the development of prognostic and diagnostic …

Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in …

Genome-wide association studies with metabolic traits (mGWAS) uncovered many genetic variants that influence human metabolism. These …

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize …

Excess body weight is a major risk factor for cardiometabolic diseases. The complex molecular mechanisms of body weight change-induced …

Individualized Medicine aims at providing optimal treatment for an individual patient at a given time based on his specific genetic and …

One of the central research questions on the etiology of Alzheimer’s disease (AD) is the elucidation of the molecular signatures …

Growth factor receptor mediated signaling is meanwhile recognized as a complex signaling network, which is initiated by recruiting …

The prioritization of candidate disease genes is often based on integrated datasets and their network representation with genes as …

Many efforts are still devoted to the discovery of genes involved with specific phenotypes, in particular, diseases. High-throughput …

Proteins and their interactions are essential for the survival of each human cell. Knowledge of their tissue occurrence is important …